RHAMM expression and isoform balance predicts aggressive disease and poor survival in multiple myeloma
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منابع مشابه
RHAMM expression and isoform balance predict aggressive disease and poor survival in multiple myeloma.
Multiple myeloma (MM) plasma cells (PCs) express receptor for hyaluronan-mediated motility (RHAMM), a hyaluronan-binding, cytoskeleton and centrosome protein. The most abundant RHAMM isoforms in MM are full-length RHAMM (RHAMMFL) and the splice variant RHAMM-exon4. We separately examined the significance of RHAMM expression, and isoform balance, in 2 groups of MM patients. In oligonucleotide mi...
متن کاملCentrosome Abnormalities in Multiple Myeloma and Receptor for Hyaluronan-Mediated Motility Correlates with
Elevated expression of receptor for hyaluronan-mediated motility (RHAMM) within ex vivo diagnostic multiple myeloma plasma cells predicts for aggressive disease and patient survival. Here, we investigate the relationship between RHAMM and centrosomal abnormalities within multiple myeloma patient samples. We report that myeloma patient samples contain pervasive structural and numerical centrosom...
متن کاملReceptor for hyaluronan-mediated motility correlates with centrosome abnormalities in multiple myeloma and maintains mitotic integrity.
Elevated expression of receptor for hyaluronan-mediated motility (RHAMM) within ex vivo diagnostic multiple myeloma plasma cells predicts for aggressive disease and patient survival. Here, we investigate the relationship between RHAMM and centrosomal abnormalities within multiple myeloma patient samples. We report that myeloma patient samples contain pervasive structural and numerical centrosom...
متن کاملHyaluronan Synthases and RHAMM as Synergistic Mediators of Malignancy in B Lineage Cancers
Hyaluronan synthases (HASs), enzymes that synthesize hyaluronan (HA), are overexpressed, and in the case of HAS1, undergo aberrant splicing in some B lineage malignancies, including multiple myeloma (MM) and Waldenstrom’s macroglobulinemia (WM). RHAMM, the receptor for HA-mediated motility, is overexpressed in malignant B lineage cells from WM, in nonHodgkin’s lymphoma (NHL), B cell chronic lym...
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Receptor for hyaluronic acid (HA)-mediated motility (RHAMM) is a nonintegral cell surface receptor involved in the aggressive phenotype in a wide spectrum of human malignancies, but the significance of RHAMM in pancreatic ductal adenocarcinoma (PDAC) remains unknown. In this study, we investigated the expression of RHAMM and its clinical relevance in PDAC. RHAMM mRNA expression was examined in ...
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